TUBA1C (tubulin alpha 1c) is an α-tubulin isoform and major structural component of microtubules, functioning as a GTP-binding protein critical for microtubule assembly and cytoskeletal organization 1. Beyond its canonical role in microtubule dynamics, TUBA1C has emerged as a pivotal oncogenic regulator across multiple cancer types. High TUBA1C expression promotes cancer progression primarily through dysregulation of cell cycle progression, particularly G1/S and G2/M phase transitions 234. In clear cell renal cell carcinoma, elevated TUBA1C activates the PI3K/AKT signaling pathway, promoting an immunosuppressive tumor microenvironment enriched in regulatory T cells and myeloid-derived suppressor cells, thereby conferring resistance to immune checkpoint blockade 1. TUBA1C upregulation is consistently associated with poor prognosis in glioma, gastric cancer, bladder carcinoma, breast cancer, and pancreatic ductal adenocarcinoma 2564. Clinically, TUBA1C represents an independent prognostic biomarker and potential therapeutic target for cancer treatment. Additionally, biallelic TUBA1C variants cause recurrent preimplantation embryo arrest through spindle assembly defects, establishing its role in female infertility 7.