WDPCP (WD repeat containing planar cell polarity effector) is a core component of the CPLANE (ciliogenesis and planar polarity effectors) complex, functioning as a critical effector in primary cilia assembly and planar cell polarity signaling 1. The protein exists as part of a crescent-shaped complex with INTU and FUZ, binding phosphatidylinositol lipids through multiple modules to regulate cilia formation and septin cytoskeleton organization 2. WDPCP is essential for intraflagellar transport by recruiting peripheral IFT-A proteins to basal bodies and likely functions as a guanine nucleotide exchange factor for Rab GTPases during ciliogenesis 3. Disruption of WDPCP causes multiple ciliopathies, including Bardet-Biedl syndrome and orofaciodigital syndrome variants featuring polysyndactyly, cardiac defects, and tongue hamartomas 45. In chr2 rhinosinusitis, reduced WDPCP expression correlates with impaired ciliogenesis and cilia dysfunction through MAPK/ERK pathway-dependent mitochondrial dysfunction 67. Additionally, WDPCP variants associate with alcohol-related liver disease pathogenesis through effects on lipid metabolism 8. These findings establish WDPCP as a multifunctional protein linking ciliary and non-ciliary processes relevant to developmental and inflammatory disease.