INTU (inturned planar cell polarity protein) is a core component of the CPLANE (ciliogenesis and planar polarity effectors) complex essential for primary cilium formation and function 1. The protein regulates ciliogenesis by controlling apical actin cytoskeleton organization and basal body positioning, which is critical for proper ciliary microtubule orientation 1. INTU forms a heterodimer with FUZ within the CPLANE complex and functions as a guanine nucleotide exchange factor (GEF) for Rab GTPases involved in ciliogenesis 2. The protein is essential for intraflagellar transport A complex assembly and functions upstream of Gli2 activation in Hedgehog signaling pathways 3. Beyond development, INTU protects adult kidney proximal tubules from ischemia-reperfusion injury by targeting STAT1 for proteasomal degradation and maintaining primary cilia 4. Disease-wise, INTU mutations cause orofaciodigital syndrome XVII, characterized by facial dysmorphism, polydactyly, brain malformations, and cardiac anomalies 56. INTU is also aberrantly upregulated in basal cell carcinoma, where it enables oncogenic Hedgehog signaling through enhanced primary cilia formation 3. The protein's downregulation correlates with reduced survival in lung adenocarcinoma and endometrial carcinoma patients 7.