WDR90 (WD repeat domain 90) is a microtubule-associated protein with dual roles in centriole architecture and immune signaling. As a centriolar microtubule wall protein, WDR90 localizes to the central core region of centrioles and is essential for maintaining centriole structural integrity 1. WDR90 depletion impairs localization of inner scaffold components and causes centriolar abnormalities 1. The protein is required for efficient primary cilium formation, with its human homolog showing functional conservation with the Chlamydomonas POC16 protein 2. Beyond its structural role, WDR90 functions as a novel component of the NLRC4 inflammasome, physically interacting with NLRC4 to enhance caspase-1 activity and promote resistance to Salmonella Typhimurium infection 3. Clinically, WDR90 variants are implicated in insomnia, with rs3752495 identified as a causal variant that increases expression of the neighboring PIG-Q gene through an intronic enhancer mechanism 4. Additionally, WDR90 expression is downregulated in Sertoli cells of non-obstructive azoospermia patients, suggesting a role in male fertility 5. WDR90 is also upregulated in WTC-exposed breast cancer cases, indicating potential epigenetic involvement in cancer pathogenesis 6.