WNT10A encodes a secreted glycoprotein that functions as a ligand for frizzled family receptors and operates through the canonical Wnt/β-catenin signaling pathway 12. The protein plays essential roles in ectodermal development, particularly in tooth development, hair follicle function, and skin appendage formation 12. WNT10A is required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium, and sweat ducts, and is necessary for proper keratin expression in these tissues 1. Mutations in WNT10A cause several autosomal recessive ectodermal dysplasia syndromes, including Odonto-onycho-dermal dysplasia and Schöpf-Schulz-Passarge syndrome, as well as selective tooth agenesis 32. Even heterozygous variants can cause ectodermal derivative impairments affecting skin, hair, sweat glands, and dental structures 1. Beyond developmental roles, WNT10A has been implicated in cancer progression, particularly in glioblastoma where it promotes malignancy through both autocrine and paracrine mechanisms 4, and in hematopoietic stem cell maintenance 5. The gene has also been associated with hidradenitis suppurativa through disruption of epidermal keratinization pathways 6.