WNT7B encodes a signaling molecule that functions as a ligand for Frizzled receptors in the canonical Wnt/β-catenin signaling pathway 1. The protein plays critical roles in vascular development and maintenance, particularly in central nervous system angiogenesis and blood-brain barrier regulation 2. WNT7B promotes choroidal neovascularization through direct effects on vascular endothelial cells, with genetic deletion of both Wnt7a and Wnt7b reducing laser-induced choroidal neovascularization in mice 3. In cancer contexts, WNT7B exhibits oncogenic properties across multiple tumor types. It is upregulated in various cancers including gastric, lung, esophageal, and pancreatic cancers 4. In glioblastoma, WNT7B expression is epigenetically activated by EZH2-HP1BP3 complexes, promoting temozolomide resistance and cancer stem cell maintenance 5. The protein also contributes to pancreatic ductal adenocarcinoma progression by activating Wnt/β-catenin signaling to maintain cancer stemness 6. Additionally, WNT7B demonstrates anti-inflammatory properties by binding FZD4 to enhance osteogenic differentiation and suppress M1 macrophage polarization in periodontal disease contexts 1. The 349-amino acid protein shows 77.1% identity with WNT7A and contains three N-linked glycosylation sites 4.