WNT7A is a secreted ligand of the Wnt family that activates canonical and non-canonical Wnt signaling pathways through interaction with frizzled receptors and co-receptors like RECK and GPR124 12. Functionally, WNT7A plays critical roles in embryonic development, including limb and skeletal patterning, urogenital tract development, and central nervous system angiogenesis with blood-brain barrier regulation 12. In the cornea, WNT7A controls epithelial cell fate determination through PAX6, maintaining limbal stem cell homeostasis and preventing keratinization-related blindness 3. WNT7A also protects articular cartilage by inhibiting IL-1Ξ²-induced matrix metalloproteinase expression through NFAT signaling, with therapeutic potential in osteoarthritis 4. In the CNS, WNT7 signaling (Wnt7a/7b) regulates glioma-vascular interactions and blood-brain barrier integrity, with implications for anti-angiogenic therapy resistance 5. Dysregulation of WNT7A is associated with multiple human diseases: recessive mutations cause severe limb and pelvic bone defects (Fuhrmann and Santos syndromes) 1, while elevated expression promotes cancer progression, including pancreatic ductal adenocarcinoma through Wnt/Ξ²-catenin pathway activation and epithelial-mesenchymal transition 6. These findings establish WNT7A as a multifunctional developmental regulator with significant disease relevance in skeletal disorders, sensory tissue homeostasis, and cancer biology.