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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
XKR7
XK related 7
Chromosome 20 Β· 20q11.21
NCBI Gene: 343702Ensembl: ENSG00000260903.3HGNC: HGNC:23062UniProt: Q5GH72
5PubMed Papers
5Diseases
0Drugs
1Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingengulfment of apoptotic cellphosphatidylserine exposure on apoptotic cell surfaceapoptotic process involved in developmentovarian dysfunctionMoyamoya diseaseataxia telangiectasiabreast carcinoma
✦AI Summary

Based on limited published evidence, XKR7 is a plasma membrane-associated protein involved in apoptotic processes. According to UniProt annotations and GO terms, XKR7 functions in protein binding, apoptotic cell development, engulfment of apoptotic cells, and phosphatidylserine exposure on apoptotic cell surfaces. Recent research identified XKR7 as a target in the miR-660-5p/XKR7 regulatory axis within gingival fibroblast-derived exosomes, where it is associated with apoptosis regulation 1.

Sources cited
1
XKR7 is targeted by miR-660-5p in gingival fibroblast-derived exosomes and is associated with apoptosis regulation
PMID: 41521291
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜5
ovarian dysfunctionOpen Targets
0.32Weak
Moyamoya diseaseOpen Targets
0.26Weak
ataxia telangiectasiaOpen Targets
0.03Suggestive
breast carcinomaOpen Targets
0.03Suggestive
neoplasmOpen Targets
0.01Suggestive
Pathogenic Variants1
NM_001011718.2(XKR7):c.1475G>A (p.Arg492His)Likely pathogenic
Moyamoya angiopathy
β˜†β˜†β˜†β˜†β†’ Residue 492
View on ClinVar β†—
Related Genes
XKR4Shared pathway100%XKR6Shared pathway100%XKR8Shared pathway60%MEGF10Shared pathway20%PLSCR2Shared pathway20%TRPC5Shared pathway7%
Tissue Expression6 tissues
Brain
100%
Bone Marrow
3%
Lung
0%
Liver
0%
Heart
0%
Ovary
0%
Gene Interaction Network
Click a node to explore
XKR7XKR4XKR6XKR8MEGF10PLSCR2TRPC5
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q5GH72
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.58Moderately Constrained
pLIβ“˜
0.82Intermediate
Observed/Expected LoF0.35 [0.22–0.58]
RankingsWhere XKR7 stands among ~20K protein-coding genes
  • #18,508of 20,598
    Most Researched5
  • #5,495of 5,498
    Most Pathogenic Variants1
  • #3,863of 17,882
    Most Constrained (LOEUF)0.58 Β· top quartile
Genes detectedXKR7
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Exosomal miRNA-mRNA interactions highlight MSC-like molecular signatures in dental pulp fibroblasts.
PMID: 41521291
Stem Cell Res Ther Β· 2026
1.00