YWHAB (14-3-3β) is an adapter protein that regulates diverse signaling pathways through phosphoserine/phosphothreonine-dependent protein binding 1. It functions as a key hub in immune and metabolic signaling networks, particularly in response to cellular stress and viral infection 2. In colon cancer, YWHAB promotes malignant progression by activating the PI3K/AKT signaling pathway through interaction with PIK3R2, regulating cell cycle progression and apoptosis 1. YWHAB inhibits hepatic gluconeogenesis through interaction with FOXO1 and GPCR; this inhibition is enhanced by OTUB1-mediated deubiquitination, suggesting therapeutic potential for type 2 diabetes 3. In cervical cancer, YWHAB knockdown reverses proliferative and invasive phenotypes, indicating its role in tumor metastasis 4. Additionally, YWHAB expression correlates with prognostic outcomes in triple-negative breast cancer through mast cell-associated immune pathways 5. In hepatocellular carcinoma, YWHAB mediates Raf/MEK/ERK signaling and represents a druggable target for inhibiting metastasis and overcoming treatment resistance 6. YWHAB also functions in neurodegenerative disease contexts, where it serves as a key hub gene in LRRK2-dependent viral responses in Parkinson's disease 2. These findings establish YWHAB as a critical regulator in cancer progression, metabolic homeostasis, and neuroinflammation.