ZC3H11B encodes a zinc finger protein that may play a role in mRNA transport, with GO annotations indicating functions in mRNA binding and poly(A)+ mRNA export from the nucleus. However, the primary evidence for ZC3H11B function comes from genetic association studies demonstrating its role in ocular development and myopia. The ZC3H11B rs4373767 polymorphism shows significant associations with high myopia and extreme myopia in Chinese populations, with the T allele conferring increased risk (OR=1.39 for high myopia, OR=1.34 for extreme myopia) 1. Meta-analysis of genome-wide association studies identified ZC3H11B as a genome-wide significant locus for axial length variation, with the minor C allele associated with decreased axial length and reduced susceptibility to high myopia (OR=0.75) 2. ZC3H11B is expressed in human neural retina, retinal pigment epithelium, and sclera, with experimental myopia models showing altered expression in murine retina and sclera 2. The gene also shows associations with corneal biomechanical properties in children 3 and has been implicated in other conditions including hernias through shared genetic architecture 4 and retinal detachment 5. These findings suggest ZC3H11B plays important roles in ocular development and refractive error beyond its potential mRNA transport function.