ZDHHC2 (zDHHC palmitoyltransferase 2) is a member of the DHHC protein family that catalyzes S-palmitoylation, a post-translational modification involving the attachment of palmitic acid to cysteine residues 1. This enzyme exhibits diverse substrate specificity, palmitoylating proteins including GSDME during chemotherapy-induced pyroptosis 1, Gpm6a to maintain mammary stem cell activity 2, USP19 to regulate ferroptosis in prostate cancer 3, and viral proteins such as influenza A hemagglutinin and M2 4. ZDHHC2 localizes to multiple cellular compartments including the endoplasmic reticulum, Golgi apparatus, and plasma membrane, facilitating protein targeting to membrane rafts and regulating synaptic function 5. The gene functions as a tumor suppressor, with reduced expression associated with metastasis and poor prognosis in hepatocellular carcinoma 6 and gastric adenocarcinoma 7. ZDHHC2 also plays critical roles in immune regulation, being essential for plasmacytoid dendritic cell-mediated inflammatory responses in psoriasis through IRF7 regulation 8. Additionally, genetic variants in ZDHHC2 are associated with schizophrenia risk in Han Chinese populations, likely affecting synaptic plasticity through PSD-95 and AKAP79/150 palmitoylation 5.