ZDHHC7 is a Golgi-localized palmitoyltransferase that catalyzes S-palmitoylation of diverse protein substrates, regulating their membrane localization and function across multiple biological processes. Beyond established roles in steroid hormone receptor signaling 1 and G protein-coupled receptor pathways 2, recent research has identified critical functions in immune regulation and cellular homeostasis. ZDHHC7 catalyzes NLRP3 inflammasome activation by palmitoylating NLRP3 at Cys126, promoting its localization to the trans-Golgi network and enabling ASC recruitment and oligomerization 34. ZDHHC7 also regulates T helper 17 cell differentiation through reversible STAT3 palmitoylation at Cys108, enhancing its membrane recruitment and phosphorylation in a cycle that can be reversed by APT2 depalmitoylation 5. During pyroptosis, ZDHHC7 palmitoylates GSDMD to direct caspase cleavage, with subsequent APT2-mediated depalmitoylation promoting pore oligomerization 6. ZDHHC7 also controls autophagosome formation by palmitoylating ATG16L1 at Cys153, facilitating LC3 lipidation 7. In disease contexts, ZDHHC7 dysregulation contributes to hepatocellular carcinoma malignancy through a positive feedback loop involving STAT3 and HIF1α 8, while elevated ZDHHC7 expression and hyperpalmitoylation promote Alzheimer's disease pathology 9. These findings suggest ZDHHC7 inhibition as a therapeutic strategy for inflammatory, neoplastic, and neurodegenerative diseases.