ZNF324 is a zinc finger transcription factor involved in cell cycle regulation and transcriptional control. As a Kruppel-type C2H2 zinc finger protein, it likely functions as a sequence-specific DNA-binding regulator of RNA polymerase II-mediated transcription 1. The protein is expressed in a cell cycle-dependent manner, with expression peaking during S phase and declining in G2/M phase, suggesting roles in G1/S transition and cell proliferation control 1. In laryngeal carcinoma pathology, ZNF324 is upregulated and functions as an oncogenic driver. The microRNA miRNA-203b-3p suppresses laryngeal cancer cell proliferation by directly targeting and inhibiting ZNF324 expression. Overexpression of ZNF324 partially reverses the anti-proliferative effects of miRNA-203b-3p, demonstrating that ZNF324 promotes clonal expansion and cell viability in cancer cells. ZNF324 upregulation correlates with advanced tumor staging and pathological grades 2. Genetically, ZNF324 variants on chromosome 19 show suggestive associations with renal uric acid excretion in Hispanic children, indicating potential roles in metabolic regulation 3. Additionally, ZNF324 has been identified as a discriminatory gene between asymptomatic/mild and severe pediatric SARS-CoV-2 infection, suggesting involvement in immune response regulation 4. Clinically, ZNF324 represents a potential therapeutic target in laryngeal carcinoma through miRNA-based interventions.