ZNF33A is a Krüppel-type zinc finger transcription factor located on chromosome 10.2 that functions as a DNA-binding transcription factor involved in transcriptional regulation 1. The gene is part of a duplicated cluster of zinc finger genes (ZNF11A, ZNF33A, ZNF37A) in the pericentromeric region of chromosome 10, with evidence suggesting functional divergence at DNA-binding residues compared to its paralog ZNF33B 2. ZNF33A has been identified as a tumor growth-promoting factor in triple-negative breast cancer (TNBC), where its overexpression correlates with worse prognosis and promotes cell proliferation 3. Mechanistically, ZNF33A facilitates resistance to bromodomain and extraterminal domain (BET) inhibitors in TNBC through upregulation of c-Myc 3. Additionally, ZNF33A expression is modulated by melatonin treatment in peripheral blood mononuclear cells, being downregulated more than twofold following melatonin exposure 4. The gene serves as a non-HLA antigen recognized by antibody responses after lung transplantation 5, and a copy number variation affecting the related ZNF33B locus has been associated with suicide attempts in major depressive disorder 6. ZNF33A represents a potential therapeutic target for sensitizing TNBC to BET inhibitor therapy.