ZNF37A is a KRAB-domain zinc finger transcription factor located on chromosome 10.2 that functions as a sequence-specific DNA-binding transcription factor regulating RNA polymerase II-dependent gene expression 1. The protein forms transcriptional regulatory complexes, as evidenced by its interaction with KAP1 to suppress THSD4 promoter activity in colorectal cancer cells 1. ZNF37A belongs to an evolutionarily duplicated gene cluster that arose through pericentric inversion during primate evolution, with a paralogous copy (ZNF37B) located at 10q11.2 2. In cancer biology, ZNF37A promotes colorectal cancer metastasis by transcriptionally repressing THSD4, leading to increased extracellular TGF-β signaling and cancer-associated fibroblast activation in the tumor microenvironment 1. Beyond cancer, ZNF37A exhibits clinical significance in multiple contexts: a pharmacogenomic variant associates with corticosteroid-induced avascular necrosis in pediatric cancer patients (OR=6.0), potentially through effects on osteoblast differentiation 3, and ZNF37A expression is downregulated in myotonic dystrophy type 1 through CUGBP1-mediated RNA destabilization, contributing to impaired myogenesis 4. Additionally, SNPs in ZNF37A associate with oleic acid composition in pork meat, suggesting roles in lipid metabolism 5.