Based on limited published evidence, ZNF628 is a transcriptional activator that binds DNA at GT-box consensus sequences (5'-TTGGTT-3') and regulates RNA polymerase II-mediated transcription. It localizes to the nucleus and functions as a DNA-binding transcription factor. UniProt annotations indicate a role in spermiogenesis. A genome-wide association study identified rare variants in ZNF628 as significantly associated with Alzheimer's disease risk, independent of APOE ε4 status 1, though the molecular mechanisms linking ZNF628 dysfunction to neurodegeneration remain unexplored.