ABCD2 (ATP binding cassette subfamily D member 2) is an ATP-dependent transporter that facilitates the transport of very long-chain fatty acids (VLCFAs) from the cytosol into peroxisomes for β-oxidation 12. The protein functions by hydrolyzing VLCFA-CoA substrates through its fatty acyl-CoA thioesterase activity, then transporting the free VLCFAs into peroxisomes in an ATP-dependent manner 2. ABCD2 shows overlapping substrate specificities with the related transporter ABCD1 but has distinct preferences for shorter VLCFAs (C22:0) and polyunsaturated fatty acids such as C22:6-CoA and C24:6-CoA 1. This substrate specificity positions ABCD2 as a key regulator of VLCFA metabolism and energy homeostasis through peroxisomal β-oxidation 1. ABCD2 has therapeutic relevance for X-linked adrenoleukodystrophy, where upregulation of ABCD2 expression can compensate for deficient ABCD1 function and restore peroxisomal β-oxidation capacity 3. The gene's expression can be induced by various compounds including LXR antagonists and 22S-hydroxycholesterol, making it a potential therapeutic target for neurodegenerative disorders involving peroxisomal dysfunction 3. Note: Several abstracts discuss the ABCD2 clinical scoring system for stroke risk, which is unrelated to this gene.