ANAPC7 is a subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase controlling mitosis and G1 phase progression 1. Unlike other APC/C components, ANAPC7 is not required for complex assembly but functions as an enzyme-substrate adapter mediating processive ubiquitination of specific substrates 2. The APC/C catalyzes formation of 'Lys-11'-linked polyubiquitin chains, with ANAPC7 contributing to branched 'Lys-11'-/'Lys-48'-linked chain assembly 13. ANAPC7 plays a critical role in brain development by directing MKI67 ubiquitination and clearance from constitutive heterochromatin following neuronal progenitor mitosis 2. Functionally, ANAPC7 modulates KIF18A-dependent mitotic progression, with variable ANAPC7 expression influencing sensitivity to KIF18A depletion in germ cells 4. Beyond canonical protein function, circular RNA derived from ANAPC7 (circANAPC7) acts as a microRNA sponge, functioning as a tumor suppressor in pancreatic cancer by sequestering miR-373 5. Dysregulation of ANAPC7 associates with multiple malignancies: upregulated protein expression correlates with poor hepatocellular carcinoma prognosis 6, while elevated circular ANAPC7 serves as a diagnostic biomarker for acute myeloid leukemia 78. In gastric cancer, ANAPC7 interacts with PD-L1 and influences immunotherapy response 9. Mutations in ANAPC7 cause Ferguson-Bonni neurodevelopmental syndrome.