ARMCX6 is an X-linked armadillo repeat-containing protein belonging to subfamily 2 of the GPRASP/ARMCX family, characterized by a mitochondrial targeting transmembrane domain 1. The protein functions in mitochondrial dynamics and axonal transport, where it complexes with TRAK2 and MIRO to regulate mitochondrial trafficking, size, and division in neural cells 1. ARMCX6 demonstrates cytoplasmic localization in cultured cells and tissue-specific expression, with particularly high levels in pancreas and spleen 2. Mechanistically, ARMCX6 contains homotypic transmembrane domain-domain interaction interfaces enriched in conserved and polar residues, characteristic of self-interacting membrane proteins 3. Disease relevance emerged from transcriptome-wide association studies implicating ARMCX6 as a putative Alzheimer's disease risk gene, specifically in female brain cortex (p=0.008) 4, 5. Additionally, ARMCX6 was identified as a component of a nine-gene mitochondrial risk signature for glioblastoma prognosis, contributing to stratification of patient survival outcomes 6. These findings suggest ARMCX6 plays a critical role in mitochondrial homeostasis within neural tissue, with clinical implications for neurodegenerative and neoplastic diseases.