Aurora Kinase C (AURKC) is a serine/threonine-protein kinase that functions as a component of the chr19 passenger complex (CPC), a key regulator of mitosis 1. AURKC plays essential roles in ensuring correct chromosome 19 and segregation at the centromere and is involved in spindle assembly and cytokinesis 2. The kinase phosphorylates histone H3 and CPC subunits including BIRC5/survivin and INCENP to regulate its own activity [UniProt]. AURKC exhibits functional redundancy with AURKB and can compensate for its loss during oocyte meiosis 2. Beyond mitotic functions, AURKC plays a critical role in spermatogenesis, where it is essential for proper meiotic progression. Mutations in AURKC cause macrozoospermia, characterized by large-headed, multi-tailed spermatozoa unsuitable for fertilization 3. Homozygous AURKC mutations lead to deficient meiosis and production of tetraploid spermatozoa, with complete sequencing recommended for diagnosis as compound heterozygotes may be missed by screening recurrent mutations alone 3. AURKC expression levels decrease with maternal age in blastocysts, suggesting age-related epigenetic influences on meiotic gene expression 4. Beyond reproductive phenotypes, AURKC polymorphisms have been associated with increased gastric cancer risk in some populations 5, highlighting broader roles in cancer susceptibility.