BIN2 (bridging integrator 2) is a membrane-sculpting N-BAR domain protein predominantly expressed in hematopoietic and leucocytic cells 1. Functionally, BIN2 promotes cell motility and migration through interactions with the cell membrane and podosome proteins that mediate cytoskeletal coupling 1. The protein modulates membrane curvature and mediates membrane tubulation, playing a critical role in podosome formation and dynamics 1. BIN2 inhibits phagocytosis, as demonstrated by increased phagocytosis upon siRNA knockdown and decreased phagocytosis upon overexpression in leucocytes 1. Mechanistically, BIN2 functions as a key component of the ORAI1-STIM1 calcium entry pathway in platelets, where it undergoes phosphorylation by protein kinase C isoforms to suppress store-regulated calcium entry and subsequently downregulate coagulation 2. BIN2 is upregulated during granulocyte differentiation and forms BAR domain-dependent complexes with Bin1 but not amphiphysin, indicating specific protein interaction preferences 3. Clinically, BIN2 has emerged as a potential biomarker and drug target: it is dysregulated in ovarian aging and fetal growth restriction, where elevated expression correlates with pathological outcomes 45; plays roles in immune dysregulation associated with preeclampsia and periodontitis 6; and is implicated in EBV-associated gastric cancer immune microenvironment remodeling 7. Polymorphisms in BIN2 associate with aging and disease-free survival, suggesting broader relevance to longevity pathways 8.