BRSK2 is a serine/threonine kinase that plays multifaceted roles in neuronal development, metabolic regulation, and disease pathogenesis. Primarily, BRSK2 regulates neuronal polarization and axonogenesis through phosphorylation of microtubule-associated proteins including tau (MAPT) and WEE1, acting downstream of the LKB1 pathway 1. Beyond neurobiology, BRSK2 modulates insulin secretion in response to glucose, with phosphorylation at different sites exerting opposing effects on secretory function 2. Diseased-associated mutations in BRSK2 cause neurodevelopmental disorders characterized by developmental delay, intellectual disability, speech delay, motor delay, and autism spectrum features, with damaging variants significantly enriched beyond background mutation rates 1. In type 2 diabetes, elevated BRSK2 expression in pancreatic β-cells promotes basal insulin hypersecretion, driving systemic insulin resistance 2. BRSK2 also plays critical roles in cancer biology: overexpression correlates with aggressive breast cancer and reduced survival, with BRSK2 regulating autophagy-mediated cell survival under nutrient deprivation via the PI3K pathway 3. Additionally, BRSK2 suppression by exosomal miR-3960 from tumor-associated fibroblasts promotes cisplatin resistance in triple-negative breast cancer 4. Recent evidence identifies BRSK2 as a significant pathogenic factor in idiopathic pulmonary fibrosis progression 5. BRSK2 represents a therapeutic target across multiple disease contexts.