CAMKV (calmodulin kinase-like vesicle-associated protein) is a synaptic protein that binds calmodulin in the presence of calcium but lacks detectable kinase activity 1, distinguishing it from other calmodulin kinase family members 2. The protein localizes to neuronal cell membranes and synapses, where it appears to participate in calcium-dependent signal transduction 2. CAMKV has emerged as a paraneoplastic autoimmune encephalitis antigen, with IgG antibodies targeting CAMKV associated with subacute neurological disease characterized by altered mental status, seizures, hyperkinetic movements, and mesial temporal lobe abnormalities 1. CAMKV-positive encephalitis shows strong associations with uterine adenocarcinoma and responsiveness to immunotherapy, though prognosis depends on concurrent malignancy 1. Beyond autoimmunity, CAMKV has genetic relevance to cognitive function; brain expression variants show causal associations with cognitive performance in Mendelian randomization analyses 3. Additionally, CAMKV variants represent putative genetic susceptibility loci for post-traumatic stress disorder identified through genome-wide association studies 4. The protein's expression in MYCN-amplified neuroblastomas makes it a candidate immunotherapeutic target in cancer 2. These diverse associations suggest CAMKV functions at the intersection of synaptic signaling, neurological autoimmunity, and neuropsychiatric disease pathogenesis.