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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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LUZP4
leucine zipper protein 4
Chromosome X · Xq23
NCBI Gene: 51213Ensembl: ENSG00000102021.11HGNC: HGNC:24971UniProt: Q9P127
10PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transporter
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingmRNA export from nucleusnucleuscytoplasmmelanomaneoplasmcancerVitiligo
✦AI Summary

Based on the provided abstracts, insufficient information is available to write a comprehensive gene function summary for LUZP4 (leucine zipper protein 4). The PubMed abstracts provided focus exclusively on autoimmune encephalitis, neurologic immune-related adverse events, neuromyelitis optica spectrum disorder, stiff person spectrum disorder, and related neurological conditions. None of these abstracts contain any information about LUZP4, its molecular function, mechanism of action, disease associations, or clinical significance. The UniProt annotation indicates that LUZP4 functions as an export adapter involved in mRNA nuclear export in cancer cells, binding and enhancing the RNA-binding activity of NXF1, but this information is not supported by any of the provided PubMed abstracts. To provide an accurate, evidence-based summary of LUZP4 function, abstracts specifically discussing this gene and its biological roles would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
melanomaOpen Targets
0.03Suggestive
neoplasmOpen Targets
0.03Suggestive
cancerOpen Targets
0.02Suggestive
VitiligoOpen Targets
0.01Suggestive
seminomaOpen Targets
0.01Suggestive
Miyoshi myopathyOpen Targets
0.01Suggestive
breast cancerOpen Targets
0.01Suggestive
paraneoplastic neurologic syndromeOpen Targets
0.00Suggestive
germ cell tumorOpen Targets
0.00Suggestive
non-small cell lung carcinomaOpen Targets
0.00Suggestive
meningiomaOpen Targets
0.00Suggestive
oral squamous cell carcinomaOpen Targets
0.00Suggestive
colorectal carcinomaOpen Targets
0.00Suggestive
gliomaOpen Targets
0.00Suggestive
Testicular Germ Cell TumorOpen Targets
0.00Suggestive
carcinomaOpen Targets
0.00Suggestive
infectionOpen Targets
0.00Suggestive
brain neoplasmOpen Targets
0.00Suggestive
multiple myelomaOpen Targets
0.00Suggestive
ovarian cancerOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
THOC3Shared pathway100%DDX39BProtein interaction100%NXF1Protein interaction98%ALYREFProtein interaction93%THOC2Protein interaction91%THOC1Protein interaction85%
Tissue Expression6 tissues
Bone Marrow
100%
Liver
0%
Heart
0%
Brain
0%
Lung
0%
Ovary
0%
Gene Interaction Network
Click a node to explore
LUZP4THOC3DDX39BNXF1ALYREFTHOC2THOC1
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q9P127
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
2.14LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF1.30 [0.82–2.14]
RankingsWhere LUZP4 stands among ~20K protein-coding genes
  • #17,098of 20,598
    Most Researched10
  • #17,849of 17,882
    Most Constrained (LOEUF)2.14
Genes detectedLUZP4
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Autoimmune Encephalitis Misdiagnosis in Adults.
PMID: 36441519
JAMA Neurol · 2023
1.00
2
International Delphi Consensus on the Management of AQP4-IgG+ NMOSD: Recommendations for Eculizumab, Inebilizumab, and Satralizumab.
PMID: 37258412
Neurol Neuroimmunol Neuroinflamm · 2023
0.90
3
Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors.
PMID: 34281989
J Immunother Cancer · 2021
0.80
4
Stiff person spectrum disorder diagnosis, misdiagnosis, and suggested diagnostic criteria.
PMID: 37212351
Ann Clin Transl Neurol · 2023
0.70
5
Magnetic Resonance Imaging Characteristics of LGI1-Antibody and CASPR2-Antibody Encephalitis.
PMID: 38497971
JAMA Neurol · 2024
0.60