Based on limited published evidence, FYTTD1 is required for mRNA export from the nucleus to the cytoplasm by acting as an adapter in the DDX39B/UAP56-NFX1 pathway, ensuring efficient mRNA delivery to nuclear pores. It associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. FYTTD1 localizes to nuclear specks and nucleoplasm, binding mRNA and proteins. In disease context, FYTTD1 is down-regulated in familial hypercholesterolemia and associated with myocardial infarction risk 1.