CAVIN3 (caveolae associated protein 3) is a multifunctional protein that plays critical roles in caveolae biology, vascular regulation, and cancer progression. CAVIN3 regulates caveolae-dependent endocytosis and trafficking, with its interaction with ROR1 being essential for proper subcellular localization and endocytic function in lung adenocarcinoma cells 1. The protein demonstrates tissue-specific functions, being required for caveolae formation in smooth muscle but dispensable in lung and heart endothelial cells. In vascular biology, CAVIN3 deficiency promotes vascular normalization in ocular neovascular diseases by inhibiting ERK/JAG1 signaling pathways, suggesting therapeutic potential for pathological angiogenesis 2. CAVIN3 expression is enriched in pancreatic endothelial cells, particularly in specialized islet capillary subpopulations involved in permeability and barrier function 3. The protein functions as a tumor suppressor in multiple cancers, with its loss promoting metastasis through AKT pathway activation 4. CAVIN3 interacts directly with BRCA1 when released from disassembled caveolae during cellular stress, participating in DNA repair mechanisms 5. Clinical studies demonstrate that low CAVIN3 expression correlates with poor prognosis in breast cancer and promotes proliferation, migration, and invasion in lung cancer 6.