CEACAM7 (CEA cell adhesion molecule 7) is a membrane-bound glycoprotein that functions as a cell adhesion molecule with restricted expression in normal tissues, primarily found on the apical surface of differentiated epithelial cells in colorectal mucosa and pancreatic ductal cells 1. The protein localizes to the plasma membrane and plays a critical role in cell migration and invasion processes across multiple cancer types 23. CEACAM7 promotes cancer cell motility through activation of specific signaling pathways, including JAK2/STAT3/BST2 in nasopharyngeal carcinoma and p-JNK/p-Src/CD317 in oral cancer 23. In normal physiology, CEACAM7 expression correlates with cell differentiation and apoptosis, being absent from highly proliferating cells at the base of colonic crypts 1. However, in malignant transformation, CEACAM7 becomes aberrantly expressed and serves as an oncogenic driver. The protein demonstrates significant clinical relevance as a prognostic biomarker, with high expression associated with poor survival outcomes in pancreatic, lung, gastric, and oral cancers 4563. CEACAM7's restricted expression profile and oncogenic properties make it an attractive therapeutic target, with CAR T-cell therapy showing efficacy against CEACAM7-positive pancreatic tumors 7.