CHRX (chordin-like 1) encodes a secreted protein that functions as an antagonist of bone morphogenetic protein (BMP) signaling by binding to BMPs and preventing their interaction with receptors 12. The protein plays crucial roles in multiple developmental and cellular processes, including neural stem cell fate determination by promoting neurogenesis over gliogenesis 3, and regulation of retinal angiogenesis through modulation of BMP4 actions in endothelial cells. In cancer biology, CHRX acts as a tumor suppressor across multiple malignancies including gastric cancer, lung adenocarcinoma, colorectal cancer, and thyroid cancer 1425. Its expression is frequently downregulated in tumor tissues through promoter hypermethylation, leading to activation of oncogenic pathways including Akt, Erk, and TGF-Ξ²/VEGF signaling 12. Loss of CHRX promotes tumor cell proliferation, migration, invasion, and angiogenesis 42. The gene is also involved in kidney disease pathophysiology, where its regulation affects BMP-SMAD signaling in proximal tubules 6. Clinically, reduced CHRX expression correlates with poor prognosis and enhanced tumor progression across various cancer types, making it a potential diagnostic biomarker and therapeutic target 75.