ZNF674 is a zinc finger protein that may be involved in transcriptional regulation, though limited research exists specifically on the protein itself 1. The gene belongs to a cluster of related zinc-finger genes on chromosome X, including ZNF41 and ZNF81, which are also implicated in X-linked mental retardation 1. ZNF674 contains Kruppel-associated box domains and zinc-finger domains crucial for DNA binding 1. Mutations in ZNF674 have been identified in patients with X-linked mental retardation, including a nonsense mutation (p.E118X) that results in a truncated protein lacking the zinc-finger domains, and amino acid substitutions that may reduce DNA-binding properties 1. However, the pathogenic significance of ZNF674 mutations has been questioned, as large-scale exome sequencing data revealed truncating variants at relatively high frequency in control populations 2. Most research focuses on ZNF674-AS1, a long non-coding RNA antisense to ZNF674, rather than the protein-coding gene itself. The clinical significance of ZNF674 mutations in intellectual disability remains uncertain and requires further validation studies.