Based on limited published evidence, ZSCAN5B is a zinc finger transcription factor involved in transcriptional regulation. It functions as an RNA polymerase II-specific DNA-binding transcription factor that localizes to the nucleus and regulates transcription through binding to cis-regulatory regions 1. ZSCAN5B also binds RNA polymerase III promoters and extra-TFIIIC sites with high specificity to conserved Pol III genes, and participates in cell-cycle regulation and mitotic progression through cooperative mechanisms with related ZSCAN family members 1. The protein exhibits DNA-binding and transcriptional regulatory activities through protein-protein interactions.