2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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11PubMed Papers
16Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETranscription Factor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
transcription cis-regulatory region bindingregulation of transcription by RNA polymerase IInucleusregulation of DNA-templated transcriptionAlzheimer diseaseParkinson diseaseDown syndromecystic fibrosis
Based on limited published evidence, ZNF585B is a zinc finger protein predicted to function as a transcriptional regulator. It localizes to the nucleus and likely binds transcription cis-regulatory regions to regulate RNA polymerase II-dependent transcription. A genome-wide CRISPR/Cas9 screen identified ZNF585B as a candidate modulating cabazitaxel resistance in castration-resistant prostate cancer 1. Additionally, rare variant analysis associated ZNF585B variants with Alzheimer's disease susceptibility 2. However, functional validation of these associations remains limited.
1
ZNF585B identified as candidate gene modulating cabazitaxel treatment response in castration-resistant prostate cancer CRISPR/Cas9 screening
PMID: 372705582
ZNF585B rare variants associated with Alzheimer's disease risk in rare variant association analysis
PMID: 35627223⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Alzheimer diseaseOpen Targets
Parkinson diseaseOpen Targets
Down syndromeOpen Targets
cystic fibrosisOpen Targets
gastric carcinomaOpen Targets
oral squamous cell carcinomaOpen Targets
acute myeloid leukemiaOpen Targets
cervical cancerOpen Targets
hepatocellular carcinomaOpen Targets
Hereditary breast cancerOpen Targets
hereditary breast carcinomaOpen Targets
ovarian serous cystadenocarcinomaOpen Targets
uterine corpus endometrial carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.