CLASP2 (cytoplasmic linker associated protein 2) is a microtubule plus-end tracking protein that plays critical roles in microtubule dynamics regulation and cellular processes. CLASP2 suppresses microtubule catastrophe and promotes rescue events without affecting microtubule growth or shrinkage rates, with these effects enhanced through synergistic interactions with EB1 protein 1. During mitosis, CLASP2 localizes to kinetochores, centrosomes, and spindles, where it regulates kinetochore-microtubule dynamics essential for chromosome 3 fidelity 23. CLASP2 exists predominantly as a monomer but can self-associate through its C-terminal domain, and its kinetochore localization helps stabilize microtubule attachments by binding to curved protofilaments at microtubule plus-ends 3. The protein enhances binding to detyrosinated microtubules during mitosis, contributing to load-bearing kinetochore attachments 4. CLASP2 also promotes cell migration and wound healing through interactions with IQGAP1 and other cytoskeletal proteins 5. In disease contexts, CLASP2 is implicated in bladder cancer progression and cisplatin resistance, promoting epithelial-mesenchymal transition and serving as a potential prognostic marker 67. Loss of CLASP2 function leads to chr3 instability and compromised mitotic fidelity in mammalian cells 2.