CPLX4 (complexin 4) is a SNARE-binding protein that regulates synaptic vesicle fusion and neurotransmitter release at synapses. While UniProt annotations indicate CPLX4 functions in SNARE complex-mediated synaptic vesicle exocytosis and synaptic transmission regulation, the provided PubMed abstracts offer limited direct functional validation. CPLX4 was identified as a gene dysregulated by gestational high-fat diet and bisphenol A co-exposure in a breast cancer susceptibility model, with altered expression associated with poor overall survival in human breast cancer cohorts 1. Additionally, CPLX4 was included in a candidate pathway study examining neurotransmitter release machinery genes in cocaine dependence, though specific associations with cocaine dependence were not reported for CPLX4 itself 2. Most recently, CPLX4 was identified as a key candidate gene affecting intramuscular lipid content and fatty acid composition in pigs through multi-omics analysis 3. These findings suggest CPLX4 may have roles beyond canonical synaptic function, potentially in metabolic regulation and disease susceptibility, though functional mechanisms in these non-neuronal contexts require further investigation.