CSNK1A1L (casein kinase 1 alpha 1 like) is a serine/threonine protein kinase that functions as a negative regulator of canonical Wnt signaling pathway 1. The protein localizes to both cytoplasm and nucleus and phosphorylates multiple protein substrates, particularly acidic proteins 1. CSNK1A1L participates in Wnt signal transduction, a pathway critical for bone homeostasis and skeletal development 2. The gene exhibits altered DNA methylation patterns in hip fracture patients compared to osteoarthritis patients, suggesting epigenetic regulation of Wnt pathway activity in bone metabolism 2. CSNK1A1L expression is regulated by microRNAs involved in osteoporotic fracture pathogenesis; miR-576-3p specifically targets CSNK1A1L to decrease its levels in osteoblasts, affecting bone formation 3. A genome-wide association study identified a novel locus near CSNK1A1L associated with coronary artery calcification in individuals with type 2 diabetes, suggesting potential cardiovascular relevance 4. Additionally, CSNK1A1L expression is dysregulated in arsenic-induced keratinocyte proliferation, implicating it in carcinogenic pathways 1. These findings indicate CSNK1A1L regulates both skeletal and cardiovascular disease susceptibility through Wnt signaling modulation.