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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
TMEM278
transmembrane protein 278
Chromosome 1 Β· 1p36.33
NCBI Gene: 643965Ensembl: ENSG00000205116.4HGNC: HGNC:37099UniProt: A6NKF7
4PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
negative regulation of canonical Wnt signaling pathwayplasma membranemembrane46,XY complete gonadal dysgenesisTesticular regression syndromehypogonadotropic hypogonadism 11 with or without anosmia46,XX ovotesticular disorder of sex development
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

transmembrane protein 278

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
46,XY complete gonadal dysgenesisOpen Targets
0.05Suggestive
Testicular regression syndromeOpen Targets
0.04Suggestive
hypogonadotropic hypogonadism 11 with or without anosmiaOpen Targets
0.04Suggestive
46,XX ovotesticular disorder of sex developmentOpen Targets
0.04Suggestive
spermatogenic failure, X-linked, 2Open Targets
0.03Suggestive
Isolated follicle stimulating hormone deficiencyOpen Targets
0.03Suggestive
colorectal carcinomaOpen Targets
0.02Suggestive
sinusitisOpen Targets
0.02Suggestive
inflammatory bowel diseaseOpen Targets
0.02Suggestive
ulcerative proctosigmoiditisOpen Targets
0.02Suggestive
papillary thyroid carcinomaOpen Targets
0.01Suggestive
alexithymiaOpen Targets
0.00Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
Abnormal emotional stateOpen Targets
0.00Suggestive
cancerOpen Targets
0.00Suggestive
colorectal cancerOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
cholangiocarcinomaOpen Targets
0.00Suggestive
clear cell renal carcinomaOpen Targets
0.00Suggestive
gastric cancerOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
TLE4Shared pathway100%TMEM131LShared pathway100%CSNK1A1LShared pathway100%TLE7Shared pathway100%TPBGLShared pathway100%TMEM170BShared pathway100%
Tissue Expression6 tissues
Brain
100%
Bone Marrow
2%
Ovary
1%
Liver
0%
Lung
0%
Heart
0%
Gene Interaction Network
Click a node to explore
TMEM278TLE4TMEM131LCSNK1A1LTLE7TPBGLTMEM170B
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt A6NKF7
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.98LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF2.54 [1.25–1.98]
RankingsWhere TMEM278 stands among ~20K protein-coding genes
  • #18,774of 20,598
    Most Researched4
  • #17,822of 17,882
    Most Constrained (LOEUF)1.98
Genes detectedTMEM278
Sources retrieved0 papers
Response timeβ€”