TMEM278 — transmembrane protein 278

4 sources retrieved · Most recent: April 2026 · Index updated 5 months ago

4PubMed Papers

#18,726 · top 96% of 19K genes

20Diseases

top 89%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

negative regulation of canonical Wnt signaling pathwayplasma membranemembraneearly-onset non-syndromic cataractretinitis pigmentosaPosterior polar cataractLeber congenital amaurosis

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

transmembrane protein 278

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

early-onset non-syndromic cataractOpen Targets

0.07Suggestive

retinitis pigmentosaOpen Targets

0.06Suggestive

Posterior polar cataractOpen Targets

0.06Suggestive

Leber congenital amaurosisOpen Targets

0.06Suggestive

Familial exudative vitreoretinopathyOpen Targets

0.06Suggestive

Total congenital cataractOpen Targets

0.06Suggestive

Cataract-microcornea syndromeOpen Targets

0.06Suggestive

Familial ocular anterior segment mesenchymal dysgenesisOpen Targets

0.06Suggestive

early-onset zonular cataractOpen Targets

0.06Suggestive

Cataract with Y-shaped suture opacitiesOpen Targets

0.06Suggestive

Peters anomalyOpen Targets

0.06Suggestive

isolated aniridiaOpen Targets

0.06Suggestive

autosomal recessive palmoplantar keratoderma and congenital alopeciaOpen Targets

0.05Suggestive

congenital primary aphakiaOpen Targets

0.05Suggestive

persistent hyperplastic primary vitreousOpen Targets

0.05Suggestive

Partial congenital cataractOpen Targets

0.05Suggestive

oculocutaneous albinism type 2Open Targets

0.05Suggestive

posterior polymorphous corneal dystrophyOpen Targets

0.05Suggestive

Cone rod dystrophyOpen Targets

0.05Suggestive

Anterior polar cataractOpen Targets

0.05Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Bone Marrow

Ovary

Liver

Lung

Heart

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt A6NKF7

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ConstraintgnomAD v4.1

LOEUFⓘ

1.98LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF2.54 [1.25–1.98]

Rankings2 dim

Where TMEM278 stands among ~20K protein-coding genes

#18,774of 20,598
Most Researched4
#17,822of 17,882
Most Constrained (LOEUF)1.98