DAZAP1 (DAZ-associated protein 1) is an RNA-binding protein containing two RNA-binding domains that functions as a splicing regulator with diverse roles in cellular metabolism and cancer progression 1. Originally identified through its interaction with infertility factors DAZ and DAZL, DAZAP1 is highly expressed in testis and shows evolutionarily conserved expression patterns across mammalian species 12. Beyond reproductive tissues, DAZAP1 plays critical roles in multiple cancer types through distinct mechanisms. In oral squamous cell carcinoma, DAZAP1 undergoes liquid-liquid phase separation to enhance COX16 expression via alternative splicing, promoting mitochondrial respiration and tumor metastasis 3. In gastric cancer, DAZAP1 maintains cancer stem cell properties by promoting mitophagy through ULK1 splicing regulation, enhancing oxidative phosphorylation 4, while also stabilizing PIN1 protein to activate MAPK signaling and chemotherapy resistance 5. DAZAP1 also serves as a fusion partner in acute lymphoblastic leukemia with MEF2D, conferring poor prognosis 6, and is identified as a recurrent driver mutation in mantle cell lymphoma 7. Additionally, DAZAP1 localizes to paraspeckles where it negatively regulates drug metabolism by suppressing PXR-mediated CYP3A4 induction 8. These findings establish DAZAP1 as a multifunctional regulator with significant therapeutic potential across hematologic and solid malignancies.