DLGAP4 (DLG associated protein 4) is a synaptic scaffold protein that plays critical roles in both neuronal development and synapse organization. The protein functions as an adapter linking ion channels to the postsynaptic cytoskeleton and may induce enrichment of PSD-95/SAP90 at the plasma membrane 1. During cortical development, DLGAP4 is strongly expressed in the ventricular zone and interacts with key proteins including EML1, where it regulates progenitor cell dynamics, morphology, proliferation, and neuronal migration 1. The protein is essential for organizing radial glial cell adherens junction components and actin cytoskeleton dynamics at the apical domain 1. Beyond its developmental roles, DLGAP4 serves as a substrate for calpain-5, a calcium-activated protease involved in synaptic protein processing 2. Clinically, DLGAP4 dysfunction is associated with neurological disorders, as chr20 translocations disrupting the gene co-segregate with cerebellar ataxia and cause epigenetic remodeling leading to dysregulated expression 3. Circular RNAs derived from DLGAP4 have emerged as potential biomarkers for acute ischemic stroke 4 and are involved in diabetic kidney disease progression through miRNA sponging mechanisms 5. The gene also shows altered expression in various cancers, suggesting broader pathological roles beyond the nervous system 6.