DNER (delta/notch like EGF repeat containing) functions as a target antigen for anti-Tr antibodies in paraneoplastic cerebellar ataxia. DNER was identified as the specific antigenic target of Tr antibodies, which are markers of cerebellar ataxia associated with Hodgkin's lymphoma 1. Anti-Tr/DNER antibody-associated cerebellar ataxia predominantly affects middle-aged males and presents as rapidly progressive isolated cerebellar dysfunction 2. The condition shows strong tumor association, with 91% of patients having an underlying malignancy, most commonly Hodgkin lymphoma 2. DNER antibodies are detected in both serum and cerebrospinal fluid of affected patients 3. While oncological treatment typically yields excellent responses (88% complete response), neurological prognosis remains poor, with only 41% of patients showing significant neurological improvement 2. The antibody testing for DNER shows high specificity and sensitivity, though positive predictive values can be moderate, particularly in serum testing 3. This autoimmune vestibulocerebellar syndrome requires early recognition and immunotherapy, as outcomes are better when treatment is initiated promptly 4. Current evidence is primarily derived from case reports and small series due to the rarity of this condition.