Based on limited published evidence, DRC11 is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary and flagellar motility that maintains axoneme alignment and integrity while regulating microtubule sliding. DRC11 functions through ATP hydrolysis activity and microtubule severing, contributing to proper cilium movement and flagellar function. Genetic defects in DRC11 are associated with primary ciliary dyskinesia (PCD) and male infertility characterized by abnormal flagellar motility, multiple morphological abnormalities of flagella (MMAF), and asthenozoospermia 1.