RSPH14 (radial spoke head 14 homolog) is a structural component of axonemal radial spoke complexes essential for ciliary and flagellar motility. It functions as part of the radial spoke 1 (RS1) stalk, contributing to the 9+2 microtubular architecture that regulates sperm flagellar beat frequency and amplitude 1. Beyond its canonical ciliary role, RSPH14 has emerged as a functionally important protein in cancer biology. In non-small cell lung cancer (NSCLC), RSPH14 is upregulated and promotes cell proliferation and cell cycle progression while suppressing apoptosis through regulation of AMPK signaling, calcium ion transport, and glucose metabolism 2. In hepatocellular carcinoma (HCC), RSPH14 functions downstream of the lnc-ZEB2-19/TRA2A regulatory axis to activate NF-κB signaling, driving tumor progression and lenvatinib resistance; RSPH14 knockdown partially reverses these oncogenic effects 3. Clinically, elevated RSPH14 expression correlates with poor prognosis in NSCLC patients, suggesting prognostic and therapeutic value. However, the mechanisms linking RSPH14's structural ciliary functions to its cancer-promoting properties remain unclear and warrant further investigation.