EML2 (EMAP like 2) is a microtubule-associated protein that plays crucial roles in microtubule dynamics and neuronal differentiation. The protein functions as a tubulin binding protein that can both inhibit microtubule nucleation and growth, and selectively interact with tyrosinated microtubules 1. EML2 exists in multiple splice variants, with the long variant (EML2-L) containing a complete N-terminal TAPE domain that promotes microtubule stabilization and neurite extension, while short variants (EML2-S) favor neurite branching during neuronal differentiation 2. The protein demonstrates unique dynamic behavior by tracking the tips of shortening microtubules and influences microtubule stability 1. Clinically, EML2 serves as a brain tissue-specific methylation marker with 100% sensitivity and specificity for forensic identification 3. The gene functions as a tumor suppressor, being significantly methylated in high-grade gliomas and associated with cancer recurrence 45. EML2 shows sex-specific expression differences in pancreatic β-cells, with higher expression in females 6, and has been implicated in nasopharyngeal carcinoma susceptibility 7.