HAUS6 is a core subunit of the HAUS augmin-like complex that regulates microtubule nucleation and organization during cell division. Its primary function involves promoting branching microtubule nucleation—the process by which new microtubules are generated from the sides of existing microtubules at defined angles 12. The calponin homology (CH) domain of HAUS6 directly binds to the microtubule lattice at inter-protofilament grooves, anchoring the augmin complex and establishing proper branching angle 12. This binding stabilizes augmin's recruitment of the γ-tubulin ring complex, essential for spindle microtubule assembly 3. HAUS6 is critical for spindle bipolarization in human oocytes; mutations impair oocyte and embryo development, contributing to infertility 4. Beyond mitosis, HAUS6 has emerging roles in disease: genome-wide association studies identify HAUS6 as a causal gene in visceral adipose tissue linked to type 2 diabetes susceptibility 5, and elevated HAUS6 expression correlates with poor prognosis in tongue squamous cell carcinoma and serves as an independent prognostic predictor 6. Additionally, HAUS6 deletion has been observed in congenital glioblastoma, potentially contributing to chr9 instability 7. These findings establish HAUS6 as both a fundamental component of mitotic machinery and an emerging biomarker in disease pathogenesis.