PCM1 (pericentriolar material 1) is a scaffolding protein essential for centrosome assembly and function 1. It nucleates centriolar satellites, membrane-less organelles surrounding centrosomes, and is required for proper localization of centrosomal proteins and microtubule anchoring to the centrosome 2. PCM1 facilitates cilium biogenesis by recruiting the BBSome complex and tubulin polyglutamylase complex to centriolar satellites, enabling efficient protein trafficking to centrioles 2. During spermatogenesis, PCM1 governs precise translocation of centrosomal proteins via intra-manchette transport, ensuring proper centrosome remodeling and flagellogenesis; PCM1 downregulation is associated with non-obstructive azoospermia, and Pcm1 knockout mice exhibit male infertility with defective sperm maturation 3. In somatic cells, PCM1 is degraded via chaperone-mediated autophagy to maintain centrosome homeostasis; DNAJA2-deficient tumors with elevated PCM1 exhibit aberrant mitosis and chromosome 8 that activates the cGAS-STING pathway 4. PCM1 deficiency in some cell types impairs early ciliogenesis through reduced mother centriole docking and CP110 removal, causing hydrocephalus and oligospermia in mice 2. Clinically, PCM1-JAK2 fusion represents a recognized genetic alteration in myeloid/lymphoid neoplasms with eosinophilia, which can be targeted therapeutically 56.