FBXO30 is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays crucial roles in muscle homeostasis and neural development. As an E3 ubiquitin ligase, FBXO30 targets multiple proteins for proteasomal degradation, including the bipolar mitotic kinesin EG5, which is essential for proper centrosome homeostasis and mitotic spindle formation 1. In muscle tissue, FBXO30 functions as a muscle ubiquitin ligase (MUSA1) that is required for muscle atrophy following denervation, with its expression negatively regulated by BMP-Smad1/5/8 signaling 2. FBXO30 also regulates neural tube development by targeting retinoic acid receptor γ (RARγ) for ubiquitination and degradation, thereby positively regulating BMP signaling during embryogenesis 3. In renal cell carcinoma, FBXO30 acts as a tumor suppressor by mediating HIF-1α ubiquitination and degradation under normoxic conditions, with its activity regulated by the hZIP1/Zn2+ pathway 4. The gene shows altered expression patterns in various pathological conditions, including upregulation during caloric restriction in muscle tissue 5 and potential involvement in polycystic ovary syndrome and Alzheimer's disease pathogenesis 67.