FHDC1 (FH2 domain containing 1) is a unique formin family protein that functions as a dual regulator of both actin and microtubule dynamics. The protein induces microtubule acetylation and stabilization while promoting actin stress fiber formation 1. FHDC1 plays a critical role in cellular organization by regulating Golgi ribbon formation through its interaction with both the Golgi-derived microtubule network and actin cytoskeleton 1. The protein is essential for primary cilia assembly, where it assists in centrosome/basal body maturation and positioning early in ciliogenesis, and subsequently promotes cilia elongation by inhibiting disassembly 2. FHDC1's mechanism involves coordination between its microtubule-binding domain and FH2 domain, which interacts with actin to maintain normal cellular architecture 1. In disease contexts, FHDC1 has been implicated in cancer progression, with upregulation observed in metastatic uveal melanoma 3 and involvement in ovarian cancer through the LINC00665/miR-181a-5p/FHDC1 regulatory axis 4. The protein has also been identified as a prognostic factor in pancreatic cancer 5 and shows altered expression in microcystin-induced hepatocyte transformation 6.