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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
H2BC15
H2B clustered histone 15
Chromosome 6 Β· 6p22.1
NCBI Gene: 8341Ensembl: ENSG00000233822.7HGNC: HGNC:4749UniProt: Q99877
81PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Hub Gene
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
nucleusextracellular exosomeinnate immune response in mucosachromatin organizationviral diseaseinfectious diseasebreast carcinomacancer
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

H2B clustered histone 15

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
infectious diseaseOpen Targets
0.50Moderate
viral diseaseOpen Targets
0.50Moderate
breast carcinomaOpen Targets
0.37Weak
cancerOpen Targets
0.37Weak
dengue diseaseOpen Targets
0.37Weak
melanomaOpen Targets
0.37Weak
prostate cancerOpen Targets
0.01Suggestive
depressive disorderOpen Targets
0.01Suggestive
heart failureOpen Targets
0.01Suggestive
type 2 diabetes mellitusOpen Targets
0.00Suggestive
posterior cortical atrophyOpen Targets
0.00Suggestive
bipolar disorderOpen Targets
0.00Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
Respiratory Syncytial Virus InfectionOpen Targets
0.00Suggestive
meningiomaOpen Targets
0.00Suggestive
acute respiratory distress syndromeOpen Targets
0.00Suggestive
autism spectrum disorderOpen Targets
0.00Suggestive
hypertrophic cardiomyopathyOpen Targets
0.00Suggestive
schizophreniaOpen Targets
0.00Suggestive
SepsisOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
H2BC13Shared pathway100%H2AC8Protein interaction100%H2AC20Protein interaction100%H3-4Protein interaction100%H3-3BProtein interaction100%H3C13Protein interaction100%
Tissue Expression6 tissues
Brain
100%
Ovary
42%
Heart
39%
Liver
37%
Bone Marrow
31%
Lung
30%
Gene Interaction Network
Click a node to explore
H2BC15H2BC13H2AC8H2AC20H3-4H3-3BH3C13
PROTEIN STRUCTURE
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PDB8OL1 Β· 3.50 Γ… Β· EM
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
1.53LoF Tolerant
pLIβ“˜
0.03Tolerant
Observed/Expected LoF0.74 [0.39–1.53]
RankingsWhere H2BC15 stands among ~20K protein-coding genes
  • #5,863of 20,598
    Most Researched81
  • #15,314of 17,882
    Most Constrained (LOEUF)1.53
Genes detectedH2BC15
Sources retrieved0 papers
Response timeβ€”