IFT22 is a Rab-like small GTPase component of the intraflagellar transport (IFT) complex B that plays critical regulatory roles in ciliary protein transport and function 1. As an active GTPase with low intrinsic GTPase activity, IFT22 functions independently of its IFT-B1 association to regulate basal body targeting of the BBSome, a coat complex essential for compartmentalizing signaling molecules within cilia 2. Specifically, IFT22 in its GTP-bound state binds and stabilizes the BBS3 GTPase, facilitating BBSome recruitment to the basal body for coupling with IFT trains, though IFT22 is not required for subsequent intra-ciliary BBSome transport 2. IFT22 maintains stable expression in both healthy and diseased tissues, exhibiting consistent involvement in ciliary assembly and anterograde transport 3. Disease relevance extends beyond classic ciliopathies; IFT22 has emerged as a novel candidate gene associated with autism spectrum disorder, identified through brain connectivity analysis with 92% diagnostic accuracy, suggesting potential roles in neuronal development beyond canonical ciliary functions 4. These findings establish IFT22 as a key regulator of ciliary protein transport and a potential contributor to neurodevelopmental disorders.