INIP (INTS3 and NABP interacting protein) is a core component of the SOSS1 complex, a multiprotein assembly functioning downstream of the MRN complex to coordinate DNA damage responses 1. INIP associates with single-stranded DNA at DNA lesions as part of the heterotrimeric sensor of ssDNA complex alongside INTS3 and hSSB1, which forms a tetrameric structure with INTS6 1. The SOSS1 complex facilitates efficient homologous recombination-dependent repair of double-strand breaks and regulates DNA:RNA hybrid dynamics through recruitment of senataxin to DSB sites, promoting removal of damage-associated RNA transcripts and R-loops 1. INIP is required for ATM-dependent signaling pathways and G2/M checkpoint activation, contributing to genomic stability maintenance. Disease relevance includes neurodevelopmental disorders, with homozygous truncating INIP variants identified in consanguineous families with intellectual disability 2, and diabetic kidney disease, where INIP-SNX30 gene-level variants associated with disease pathogenesis 3. In pediatric B-cell precursor acute lymphoblastic leukemia, recurrent INIP deletions were identified, predominantly in cases with t(12;21) translocation 4. These findings establish INIP as a multifunctional DNA repair component with critical roles in genomic stability and disease susceptibility.