KIAA1328 is a protein-binding factor that competes with SMC1 for binding to SMC3, thereby modulating the assembly of cohesin and related multimeric protein complexes 1. As a cilia basal body/centriolar satellite protein, KIAA1328 plays a structural role in centrosome organization 2. While KIAA1328 disruption is not independently associated with known disease, it was identified as a co-deleted gene in a 275 kb deletion at chromosome 18.2 alongside CELF4 in patients with developmental delay, intellectual disability, seizures, and autism spectrum disorders 3. The clinical manifestation of this deletion phenotype appears primarily attributable to CELF4 haploinsufficiency rather than KIAA1328 loss, as KIAA1328 disruption alone shows no documented pathogenic consequence 3. KIAA1328's molecular function in regulating SMC3 availability suggests potential relevance to chr18 stability maintenance, though clinical significance remains unclear without disease-specific mutations or functional studies demonstrating pathogenic mechanisms independent of co-deletion contexts.