KIF26B (kinesin family member 26B) is a microtubule-associated protein with dual roles in developmental and pathological contexts. During embryonic development, KIF26B is essential for kidney development, where it facilitates compact adhesion between mesenchymal cells adjacent to ureteric buds, possibly through interaction with MYH10 to establish basolateral mesenchymal integrity and maintain GDNF-dependent ureteric bud attraction 1. In adult pathology, KIF26B functions as an oncogenic driver across multiple cancer types. In bladder cancer, KIF26B promotes progression through two distinct mechanisms: activating Wnt/β-catenin signaling via TRAF2-dependent pathways 2 and driving RNA m5C modification through NSUN2 nuclear translocation, establishing a KIF26B/NSUN2/m5C/IL-6 positive feedback loop 3. In colorectal cancer, KIF26B expression is upregulated when METTL3-mediated m6A modifications are reduced, correlating with metastasis and poor survival 4. Similar oncogenic roles are documented in ovarian cancer 5, colon adenocarcinoma 6, and oral squamous cell carcinoma, where KIF26B promotes proliferation, migration, and invasion through GSK-3β/β-catenin pathway activation 7. Genetic polymorphisms in KIF26B are associated with keratoconus susceptibility 8. High KIF26B expression correlates with reduced overall survival across malignancies and represents a promising therapeutic target.